Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review2-Pyridylethylamine dihydrochloride
Description: H1 agonist
Chemical Name: 2-Pyridineethanamine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for 2-Pyridylethylamine dihydrochloride
2-Pyridylethylamine dihydrochloride is a histamine H1 receptor agonist that produces vasoconstriction in vivo.
Compound Libraries for 2-Pyridylethylamine dihydrochloride
2-Pyridylethylamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 2-Pyridylethylamine dihydrochloride
| M. Wt | 195.09 |
| Formula | C7H10N2.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 3343-39-3 |
| PubChem ID | 201148 |
| InChI Key | GPIFKSYYILNJNR-UHFFFAOYSA-N |
| Smiles | Cl.Cl.NCCC1=NC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-Pyridylethylamine dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.51 | 100 | |
| DMSO | 9.75 | 50 |
Preparing Stock Solutions for 2-Pyridylethylamine dihydrochloride
The following data is based on the product molecular weight 195.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.13 mL | 25.63 mL | 51.26 mL |
| 5 mM | 1.03 mL | 5.13 mL | 10.25 mL |
| 10 mM | 0.51 mL | 2.56 mL | 5.13 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.03 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 2-Pyridylethylamine dihydrochloride
References for 2-Pyridylethylamine dihydrochloride
References are publications that support the biological activity of the product.
Martinez-Mir et al (1992) Effect of histamine and histamine analogues on human isolated myometrial strips. Br.J.Pharmacol. 107 528 PMID: 1358393
Arai and Chiba (1999) Endothelium-dependent vasodilation mechanisms by histamine in simian but not in canine femoral arterial branches. J.Auton.Pharmacol. 19 267 PMID: 10759332
If you know of a relevant reference for 2-Pyridylethylamine dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 2-Pyridylethylamine dihydrochloride, 2-Pyridylethylamine dihydrochloride supplier, H1, receptor, agonists, Receptors, Histamine, histaminergic, 2478, Tocris Bioscience
2 Citations for 2-Pyridylethylamine dihydrochloride
Citations are publications that use Tocris products. Selected citations for 2-Pyridylethylamine dihydrochloride include:
Jain et al (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315 E357 PMID: 29812984
Ashina et al (2015) Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. Mol Med Rep 10 e0132367 PMID: 26158531
Do you know of a great paper that uses 2-Pyridylethylamine dihydrochloride from Tocris? Please let us know.
Reviews for 2-Pyridylethylamine dihydrochloride
There are currently no reviews for this product. Be the first to review 2-Pyridylethylamine dihydrochloride and earn rewards!
Have you used 2-Pyridylethylamine dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.