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Submit Review22-Oxacalcitriol
Description: Non-calcemic vitamin D3 (Cat. No. 4156) analog
Alternative Names: Maxacalcitol
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥95% (HPLC)
Biological Activity for 22-Oxacalcitriol
22-Oxacalcitriol is a non-calcemic vitamin D3 (Cat. No. 4156) analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Exhibits similar effects to calcitriol (Cat. No. 2551) in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.
Technical Data for 22-Oxacalcitriol
| M. Wt | 418.61 |
| Formula | C26H42O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 103909-75-7 |
| PubChem ID | 6398761 |
| InChI Key | DTXXSJZBSTYZKE-ZDQKKZTESA-N |
| Smiles | C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](OCCC(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 22-Oxacalcitriol
References for 22-Oxacalcitriol
References are publications that support the biological activity of the product.
Monier-Faugere et al (1999) 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. 55 821 PMID: 10027919
Barroga et al (2000) Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. 68 79 PMID: 10684763
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Keywords: 22-Oxacalcitriol, 22-Oxacalcitriol supplier, 22-Oxacalcitriol, OCT, vitamin, D, analogue, analog, non-calcemic, VDR, Maxacalcitol, Vitamin, Receptors, 4160, Tocris Bioscience
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