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Submit Review3',2'-cGAMP sodium salt
Description: Induces expression of STING and STING-related genes; antiviral
Chemical Name: 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Biological Activity for 3',2'-cGAMP sodium salt
3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.
Technical Data for 3',2'-cGAMP sodium salt
| M. Wt | 718.38 |
| Formula | C20H22N10Na2O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| InChI Key | ROQCYAKTZSZNCA-DQNSRKNCSA-L |
| Smiles | O[C@H]1[C@@]2([C@@]([H])(O[C@@]1(COP([O-])(O[C@@]3([C@@]([H])(COP([O-])(O2)=O)O[C@]([H])([C@@H]3O)N4C5=C(N=C4)C(N=C(N)N5)=O)[H])=O)[H])N6C7=NC=NC(N)=C7N=C6)[H].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3',2'-cGAMP sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.18 | 10 |
Preparing Stock Solutions for 3',2'-cGAMP sodium salt
The following data is based on the product molecular weight 718.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.92 mL | 69.6 mL | 139.2 mL |
| 0.5 mM | 2.78 mL | 13.92 mL | 27.84 mL |
| 1 mM | 1.39 mL | 6.96 mL | 13.92 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
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Product Datasheets for 3',2'-cGAMP sodium salt
References for 3',2'-cGAMP sodium salt
References are publications that support the biological activity of the product.
Slavik et al (2021) cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 597 109 PMID: 34261127
Fatma et al (2021) Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 12 6831 PMID: 34737303
If you know of a relevant reference for 3',2'-cGAMP sodium salt, please let us know.
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Citations for 3',2'-cGAMP sodium salt
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