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Submit Review3',3'-cGAMP sodium salt
Description: STING agonist
Chemical Name: 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Biological Activity for 3',3'-cGAMP sodium salt
3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.
This product is sold in units of 359μg, equivalent to 0.5μmol.
Technical Data for 3',3'-cGAMP sodium salt
| M. Wt | 718.37 |
| Formula | C20H22N10Na2O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2407516-83-8 |
| PubChem ID | 121513907 |
| InChI Key | MFPHQIYDBUVTRL-DQNSRKNCSA-L |
| Smiles | [H][C@@]12COP(O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O[C@@]1([H])[C@@H](O)[C@@H](O2)N4C=NC5=C4N=C(NC5=O)N)(O[Na])=O)N6C=NC7=C(N)N=CN=C67)(O[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3',3'-cGAMP sodium salt
References for 3',3'-cGAMP sodium salt
References are publications that support the biological activity of the product.
Tang et al (2016) Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76 2137 PMID: 26951929
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Keywords: 3',3'-cGAMP sodium salt, 3',3'-cGAMP sodium salt supplier, STING, agonists, malignant, B-cells, STING-Dependent, Signaling, 5946, Tocris Bioscience
1 Citation for 3',3'-cGAMP sodium salt
Citations are publications that use Tocris products. Selected citations for 3',3'-cGAMP sodium salt include:
Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734
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