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Submit Review3'-Fluorobenzylspiperone maleate
Description: D2-like receptor ligand
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-(3-fluorobenzyl-1-phenyl)-1,3,8-triazaspiro[4,5]decan-4-one maleate
Purity: ≥98% (HPLC)
Biological Activity for 3'-Fluorobenzylspiperone maleate
3'-Fluorobenzylspiperone maleate is a very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors.
Technical Data for 3'-Fluorobenzylspiperone maleate
| M. Wt | 619.67 |
| Formula | C30H31F2N3O2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1135278-61-3 |
| PubChem ID | 24978532 |
| InChI Key | JURUFADWVGXLOY-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3'-Fluorobenzylspiperone maleate
References for 3'-Fluorobenzylspiperone maleate
References are publications that support the biological activity of the product.
Mach et al (1992) Effect of N-alkylation on the affinities of analogues of spiperone for DA D2 and serotonin 5-HT2 receptors. J.Med.Chem. 35 423 PMID: 1531364
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Keywords: 3'-Fluorobenzylspiperone maleate, 3'-Fluorobenzylspiperone maleate supplier, D2-like, ligand, Dopamine, Non-Selective, Receptors, dopaminergic, 3-Fluorobenzylspiperone, maleate, Non-selective, 0701, Tocris Bioscience
Citations for 3'-Fluorobenzylspiperone maleate
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Currently there are no citations for 3'-Fluorobenzylspiperone maleate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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