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Submit Review3-Mercaptopicolinic acid hydrochloride
Description: Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis
Chemical Name: 3-Mercapto-2-pyridinecarboxylic acid hydrochloride
Biological Activity for 3-Mercaptopicolinic acid hydrochloride
3-Mercaptopicolinic acid hydrochloride is a phospoenolpyruvate carboxykinase (PEPCK) inhibitor (IC50 = 7.5 μM at hPEPCK). Inhibits glucose synthesis. In vitro, 3-Mercaptopicolinic acid reduces proliferation of Treg cells, induces myogenic differentiation of C2C12 cells, and reduces colony growth formation of MCF7 cells. Also sensitizes melanoma cells to Vemurafenib (Cat. No. 7309) via inhibition of cytoplasmic PEPCK.
Technical Data for 3-Mercaptopicolinic acid hydrochloride
| M. Wt | 191.63 |
| Formula | C6H5NO2S.HCl |
| Storage | Store at -20°C |
| CAS Number | 320386-54-7 |
| PubChem ID | 24721311 |
| InChI Key | DYGYEUUVNLEHJP-UHFFFAOYSA-N |
| Smiles | O=C(C1=NC=CC=C1S)O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3-Mercaptopicolinic acid hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.83 | 20 | |
| water | 1.92 | 10 |
Preparing Stock Solutions for 3-Mercaptopicolinic acid hydrochloride
The following data is based on the product molecular weight 191.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 26.09 mL | 130.46 mL | 260.92 mL |
| 1 mM | 5.22 mL | 26.09 mL | 52.18 mL |
| 2 mM | 2.61 mL | 13.05 mL | 26.09 mL |
| 10 mM | 0.52 mL | 2.61 mL | 5.22 mL |
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Product Datasheets for 3-Mercaptopicolinic acid hydrochloride
References for 3-Mercaptopicolinic acid hydrochloride
References are publications that support the biological activity of the product.
Watson et al (2021) Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature 591 645 PMID: 33589820
Mcleod et al (2019) Characterization of 3-[(carboxymethyl)thio]picolinic acid: a novel inhibitor of phosphoenolpyruvate carboxykinase. Biochemistry 58 3918 PMID: 31461616
Brearley et al (2020) The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Sci.Rep. 10 22177 PMID: 33335245
Aragó et al (2020) Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M. Biomed.Pharmacother. 121 109601 PMID: 31739159
Ren et al (2022) Overcoming chemoresistance to b-raf inhibitor in melanoma via targeted inhibition of phosphoenolpyruvate carboxykinase1 using 3-mercaptopropionic acid. Bioengineered 13 13571
If you know of a relevant reference for 3-Mercaptopicolinic acid hydrochloride, please let us know.
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Citations for 3-Mercaptopicolinic acid hydrochloride
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