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Discontinued Product
0581 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: α1 ligand
Chemical Name: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
Biological Activity for 3-MPPI
Very potent ligand for α1 sites (Ki for displacement of prazosin = 0.2 nM). Displays different binding properties for each α1 subtype (pKi values are 8.74, 9.44 and 9.57 for α1B, α1D and α1A adrenoceptors respectively). Also binds to 5-HT1A sites (Ki = 50 nM).
Technical Data for 3-MPPI
| M. Wt | 419.48 |
| Formula | C23H25N5O3 |
| Storage | Store at RT |
| CAS Number | 133399-65-2 |
| PubChem ID | 4013695 |
| InChI Key | AQASGOHUMGAWJJ-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC=C1)N1CCN(CCN2C(=O)NC3=C(NC4=CC=CC=C34)C2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-MPPI
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
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References for 3-MPPI
References are publications that support the biological activity of the product.
Russo et al (1991) Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands. J.Med.Chem. 34 1850 PMID: 1648138
Romeo et al (2003) New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes. J.Med.Chem. 46 2877 PMID: 12825930
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Keywords: 3-MPPI, 3-MPPI supplier, 5-HT1A, ligand, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, Serotonin, Receptors, 5-HT1, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Adrenergic, Alpha-1, 0581, Tocris Bioscience
Citations for 3-MPPI
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Currently there are no citations for 3-MPPI.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.