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Submit Review4-Acetyl-1,1-dimethylpiperazinium iodide
Discontinued Product
0352 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: nAChR agonist
Biological Activity
4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.
Technical Data
| M. Wt | 284.14 |
| Formula | C8H17IN2O |
| Storage | Store at RT |
| CAS Number | 75667-84-4 |
| PubChem ID | 5311072 |
| InChI Key | VXBLRKDEHGKPAC-UHFFFAOYSA-M |
| Smiles | C[N+]1(C)CCN(CC1)C(=O)C.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625
Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051
Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289
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Keywords: 4-Acetyl-1,1-dimethylpiperazinium iodide, 4-Acetyl-1,1-dimethylpiperazinium iodide supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, (Non-selective), 0352, Tocris Bioscience
Citations for 4-Acetyl-1,1-dimethylpiperazinium iodide
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Currently there are no citations for 4-Acetyl-1,1-dimethylpiperazinium iodide.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.