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Submit Review4-PPBP maleate
Description: Specific σ ligand, NMDA antagonist
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity: ≥99% (HPLC)
Biological Activity for 4-PPBP maleate
4-PPBP maleate is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.
Technical Data for 4-PPBP maleate
| M. Wt | 409.52 |
| Formula | C21H27N.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 201216-39-9 |
| PubChem ID | 11682970 |
| InChI Key | OASPNIMFGJVLES-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.C(CCC1=CC=CC=C1)CN1CCC(CC1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4-PPBP maleate
References for 4-PPBP maleate
References are publications that support the biological activity of the product.
Glennon et al (1991) Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 34 3360 PMID: 1662725
Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
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Keywords: 4-PPBP maleate, 4-PPBP maleate supplier, Specific, σ, sigma, ligand, NMDA, antagonists, Receptors, Sigma-Related, 0620, Tocris Bioscience
1 Citation for 4-PPBP maleate
Citations are publications that use Tocris products. Selected citations for 4-PPBP maleate include:
Yang et al (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci 104 1179 PMID: 17456670
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