Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review4E1RCat
Description: Inhibits eIF4F subunit interaction; inhibits protein translation
Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for 4E1RCat
4E1RCat is an inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
Technical Data for 4E1RCat
| M. Wt | 478.45 |
| Formula | C28H18N2O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 328998-25-0 |
| PubChem ID | 16195554 |
| InChI Key | BBQRBOIMSKMFFO-LTGZKZEYSA-N |
| Smiles | O=C1N(C3=CC=C(C(O)=O)C=C3)C(C4=CC=CC=C4)=C/C1=C\C2=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4E1RCat
References for 4E1RCat
References are publications that support the biological activity of the product.
Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046
View Related Products by Target
Keywords: 4E1RCat, 4E1RCat supplier, eIF4F, inhibitors, inhibits, protein, synthesis, chemosensitizing, chemosensitizer, cap, dependent, translation, eIF4E, eIF4G, 4E-BP1, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4215, Tocris Bioscience
1 Citation for 4E1RCat
Citations are publications that use Tocris products. Selected citations for 4E1RCat include:
Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284 PMID: 25062042
Reviews for 4E1RCat
There are currently no reviews for this product. Be the first to review 4E1RCat and earn rewards!
Have you used 4E1RCat?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image