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Description: Inhibits IRE1α endoribonuclease activity
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity: ≥98%
Biological Activity for 4μ8C
4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
Compound Libraries for 4μ8C
4mu8C is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 4μ8C
| M. Wt | 204.18 |
| Formula | C11H8O4 |
| Storage | Store at -20°C |
| Purity | ≥98% |
| CAS Number | 14003-96-4 |
| PubChem ID | 12934390 |
| InChI Key | RTHHSXOVIJWFQP-UHFFFAOYSA-N |
| Smiles | CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4μ8C
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.42 | 100 |
Preparing Stock Solutions for 4μ8C
The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.9 mL | 24.49 mL | 48.98 mL |
| 5 mM | 0.98 mL | 4.9 mL | 9.8 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets for 4μ8C
References for 4μ8C
References are publications that support the biological activity of the product.
Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414
If you know of a relevant reference for 4μ8C, please let us know.
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Keywords: 4mu8C, 4mu8C supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, 4u8c, IRE1, 4479, Tocris Bioscience
10 Citations for 4μ8C
Citations are publications that use Tocris products. Selected citations for 4μ8C include:
Amin-Wetzel et al (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625 PMID: 29198525
Mart et al (2021) The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem 296 100295 PMID: 33460650
Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFNα production in humans Cytokine 94 55 PMID: 28408069
Lisa G M et al (2022) Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation. Cell Mol Life Sci 79 231 PMID: 35396971
Li-ying et al (2022) CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int J Mol Sci 23 PMID: 36012764
Judith A et al (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med 11 PMID: 30728287
Benoit et al (2019) Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell 177 1201-1216.e19 PMID: 31031005
Mihee M et al (2019) Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology. Curr Protoc Pharmacol 85 e54 PMID: 30920154
Yahui et al (2019) Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. Elife 8 PMID: 31873072
Yuren et al (2020) Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells. PLoS One 14 e0226940 PMID: 31891641
Do you know of a great paper that uses 4μ8C from Tocris? Please let us know.
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets