Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review5-Amino-Thalidomide
Description: Cereblon ligand with amine on C5 for onward chemistry
Chemical Name: 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Biological Activity for 5-Amino-Thalidomide
5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.
Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for 5-Amino-Thalidomide
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for 5-Amino-Thalidomide
| M. Wt | 273.24 |
| Formula | C13H11N3O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 191732-76-0 |
| InChI Key | IICWMVJMJVXCLY-UHFFFAOYSA-N |
| Smiles | O=C1C2=CC=C(N)C=C2C(=O)N1C3C(=O)NC(=O)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 5-Amino-Thalidomide
References for 5-Amino-Thalidomide
References are publications that support the biological activity of the product.
Nguyen et al (2021) Proteolysis Targeting Chimeras With Reduced Off-targets. bioRxiv
If you know of a relevant reference for 5-Amino-Thalidomide, please let us know.
View Related Products by Target
Keywords: 5-Amino-Thalidomide, 5-Amino-Thalidomide supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, amine, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, CRBN, rigid, linker, semi-rigid, cross-linker, rigidity, Functionalized, Ligase, Ligands, 7678, Tocris Bioscience
Citations for 5-Amino-Thalidomide
Citations are publications that use Tocris products.
Currently there are no citations for 5-Amino-Thalidomide. Do you know of a great paper that uses 5-Amino-Thalidomide from Tocris? Please let us know.
Reviews for 5-Amino-Thalidomide
There are currently no reviews for this product. Be the first to review 5-Amino-Thalidomide and earn rewards!
Have you used 5-Amino-Thalidomide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia