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Submit Review6'-Iodoresiniferatoxin
Description: High affinity TRPV1 agonist/partial agonist
Alternative Names: 6'-IRTX
Chemical Name: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
Purity: ≥98% (HPLC)
Biological Activity for 6'-Iodoresiniferatoxin
High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.
Technical Data for 6'-Iodoresiniferatoxin
| M. Wt | 754.6 |
| Formula | C37H39IO9 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 335151-55-8 |
| PubChem ID | 10305903 |
| InChI Key | IITCVPTZKLXSKQ-ZSVIJTOTSA-N |
| Smiles | O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=C(I)C=C(O)C(OC)=C5)=O)=C[C@]3([H])[C@@](O6)2[C@H](C)C[C@@]4(C(C)=C)[C@@H]3OC6(CC7=CC=CC=C7)O4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 6'-Iodoresiniferatoxin
References for 6'-Iodoresiniferatoxin
References are publications that support the biological activity of the product.
McDonnell et al (2002) Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg.Med.Chem.Lett. 12 1189 PMID: 11934585
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Keywords: 6'-Iodoresiniferatoxin, 6'-Iodoresiniferatoxin supplier, High, affinity, TRPV1, agonists, partial, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 6-Iodoresiniferatoxin, 6-IRTX, 6'-IRTX, 1556, Tocris Bioscience
Citations for 6'-Iodoresiniferatoxin
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