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Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
Purity: ≥98% (HPLC)
Biological Activity for 673 A
673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.
Technical Data for 673 A
| M. Wt | 223.28 |
| Formula | C15H13NO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 109437-62-9 |
| PubChem ID | 969428 |
| InChI Key | GSAVXYHVHQTGEA-UHFFFAOYSA-N |
| Smiles | O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 673 A
References for 673 A
References are publications that support the biological activity of the product.
Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894
Raghavan et al (2017) Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 23 6934 PMID: 28814433
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