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7-Chlorokynurenic acid sodium salt

Cat. No. 3697 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 7-Chlorokynurenic acid sodium salt

7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Technical Data for 7-Chlorokynurenic acid sodium salt

M. Wt 245.59
Formula C10H5ClNNaO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1263094-00-3
PubChem ID 52974249
InChI Key IFZYIORLNGNLEI-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 7-Chlorokynurenic acid sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.56 100

Preparing Stock Solutions for 7-Chlorokynurenic acid sodium salt

The following data is based on the product molecular weight 245.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.07 mL 20.36 mL 40.72 mL
5 mM 0.81 mL 4.07 mL 8.14 mL
10 mM 0.41 mL 2.04 mL 4.07 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for 7-Chlorokynurenic acid sodium salt

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for 7-Chlorokynurenic acid sodium salt

References are publications that support the biological activity of the product.

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37 PMID: 7498252

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839 PMID: 9776380

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 85 6547

Donald et al (1988) Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P

If you know of a relevant reference for 7-Chlorokynurenic acid sodium salt, please let us know.

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Keywords: 7-Chlorokynurenic acid sodium salt, 7-Chlorokynurenic acid sodium salt supplier, Potent, competitive, inhibitors, inhibits, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3697, Tocris Bioscience

2 Citations for 7-Chlorokynurenic acid sodium salt

Citations are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid sodium salt include:

Jun Kyu et al (2021) Projection-dependent heterogeneity of cerebellar granule cell calcium responses. Mol Brain 14 63 PMID: 33789707

Roberto et al (2021) PSD-95 protects synapses from β-amyloid. Cell Rep 35 109194 PMID: 34077732

Do you know of a great paper that uses 7-Chlorokynurenic acid sodium salt from Tocris? Please let us know.

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Literature in this Area

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