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Submit Review8-Aminoadenine
Description: Adenine receptor agonist
Chemical Name: 9H-Purine-6,8-diamine
Purity: ≥98% (HPLC)
Biological Activity for 8-Aminoadenine
8-Aminoadenine is an adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).
Technical Data for 8-Aminoadenine
| M. Wt | 150.14 |
| Formula | C5H6N6 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 28128-33-8 |
| PubChem ID | 4371597 |
| InChI Key | PFUVOLUPRFCPMN-UHFFFAOYSA-N |
| Smiles | NC2=NC1=NC=NC(N)=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 8-Aminoadenine
References for 8-Aminoadenine
References are publications that support the biological activity of the product.
Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974 PMID: 19731917
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573
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Keywords: 8-Aminoadenine, 8-Aminoadenine supplier, p0, adenine, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4050, Tocris Bioscience
Citations for 8-Aminoadenine
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Currently there are no citations for 8-Aminoadenine.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.