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Submit Review8-Hydroxy-PIPAT oxalate
Description: High affinity 5-HT1A agonist
Chemical Name: (RS)-trans-8-Hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin oxalate
Purity: ≥98% (HPLC)
Biological Activity for 8-Hydroxy-PIPAT oxalate
8-Hydroxy-PIPAT oxalate is a high affinity 5-HT1A receptor agonist (Kd = 0.38 nM).
7-Hydroxy Isomer also available.
Licensing Information
Sold with the permission of the University of Pennsylvania
Technical Data for 8-Hydroxy-PIPAT oxalate
| M. Wt | 461.3 |
| Formula | C16H22INO.C2H2O4 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1451210-48-2 |
| PubChem ID | 56972162 |
| InChI Key | XIBSIFOFYWBOAQ-JOKMOOFLSA-N |
| Smiles | [H]OC(=O)C(=O)O[H].CCCN(C\C=C\I)C1CCC2=CC=CC(O)=C2C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 8-Hydroxy-PIPAT oxalate
References for 8-Hydroxy-PIPAT oxalate
References are publications that support the biological activity of the product.
Zhuang et al (1993) Synthesis of (R,S)-trans-8-Hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J.Med.Chem. 36 3161 PMID: 8230102
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Keywords: 8-Hydroxy-PIPAT oxalate, 8-Hydroxy-PIPAT oxalate supplier, High, affinity, 5-HT1A, agonists, Serotonin, Receptors, 0797, Tocris Bioscience
Citations for 8-Hydroxy-PIPAT oxalate
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Currently there are no citations for 8-Hydroxy-PIPAT oxalate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.