Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review8MDP
Description: Potent equilibrative nucleoside transporter (ENT) inhibitor
Chemical Name: 2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
Purity: ≥98% (HPLC)
Biological Activity for 8MDP
8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively.
Compound Libraries for 8MDP
8MDP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 8MDP
| M. Wt | 560.73 |
| Formula | C28H48N8O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 29491-75-6 |
| PubChem ID | 16756415 |
| InChI Key | KXOCTHJHIGLQKJ-UHFFFAOYSA-N |
| Smiles | OCCN(CCO)C2=NC1=C(N3CCCCCCC3)N=C(N(CCO)CCO)N=C1C(N4CCCCCCC4)=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 8MDP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.21 | 20 |
Preparing Stock Solutions for 8MDP
The following data is based on the product molecular weight 560.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.92 mL | 44.58 mL | 89.17 mL |
| 1 mM | 1.78 mL | 8.92 mL | 17.83 mL |
| 2 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 8MDP
References for 8MDP
References are publications that support the biological activity of the product.
Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID: 21539390
Lin et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949
If you know of a relevant reference for 8MDP, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 8MDP, 8MDP supplier, ENT1, inhibitors, inhibits, potent, equilibrative, nucleoside, transporters, 1, 2, ENT2, transports, Nucleoside, Transporters, 4588, Tocris Bioscience
Citations for 8MDP
Citations are publications that use Tocris products.
Currently there are no citations for 8MDP. Do you know of a great paper that uses 8MDP from Tocris? Please let us know.
Reviews for 8MDP
There are currently no reviews for this product. Be the first to review 8MDP and earn rewards!
Have you used 8MDP?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image