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Description: Allosteric inhibitor of glutaminase
Chemical Name: 5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
Purity: ≥99% (HPLC)
Biological Activity for 968
968 is an allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.
Technical Data for 968
| M. Wt | 475.42 |
| Formula | C27H27BrN2O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 311795-38-7 |
| PubChem ID | 3099980 |
| InChI Key | NVFRRJQWRZFDLM-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C(C5=C4CC(C)(C)CC5=O)NC3=C4C2=CC=CC=C2C=C3)=CC=C1N(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 968
References for 968
References are publications that support the biological activity of the product.
Wang et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18 207 PMID: 20832749
Stalnecker et al (2015) Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 112 394 PMID: 25548170
Lu et al (2010) Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 18 199 PMID: 20832746
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Keywords: 968, 968 supplier, Hydrolases, allosteric, inhibitors, inhibits, glutaminase, oncogene, transformation, gls1, Glutaminase, 5460, Tocris Bioscience
Citations for 968
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