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Description: High affinity retinol-binding protein 4 (RBP4) ligand
Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Purity: ≥99% (HPLC)
Biological Activity for A 1120
A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.
Compound Libraries for A 1120
A 1120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for A 1120
| M. Wt | 392.37 |
| Formula | C20H19F3N2O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1152782-19-8 |
| PubChem ID | 25138295 |
| InChI Key | MEAQCLPMSVEOQF-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 1120
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 | |
| ethanol | 9.81 | 25 |
Preparing Stock Solutions for A 1120
The following data is based on the product molecular weight 392.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.49 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for A 1120
References for A 1120
References are publications that support the biological activity of the product.
Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 140 311 PMID: 20032483
Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673 PMID: 19147488
If you know of a relevant reference for A 1120, please let us know.
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Keywords: A 1120, A 1120 supplier, A1120, non-retinoid, retinol-binding, proteins, 4, RBP4, ligands, adipokines, transthyretin, TTR, Miscellaneous, Compounds, 3793, Tocris Bioscience
1 Citation for A 1120
Citations are publications that use Tocris products. Selected citations for A 1120 include:
Du et al (2017) Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci 58 4375–4383 PMID: 28813718
Do you know of a great paper that uses A 1120 from Tocris? Please let us know.
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