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Submit ReviewA 331440 dihydrochloride
Discontinued Product
4697 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Selective H3 antagonist
Chemical Name: 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for A 331440 dihydrochloride
A 331440 dihydrochloride is a high affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.
Technical Data for A 331440 dihydrochloride
| M. Wt | 422.39 |
| Formula | C22H27N3O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1049740-32-0 |
| PubChem ID | 16078942 |
| InChI Key | XFPYVTSGYYMTFS-GHVWMZMZSA-N |
| Smiles | CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 331440 dihydrochloride
References for A 331440 dihydrochloride
References are publications that support the biological activity of the product.
Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183 PMID: 15033391
Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144 PMID: 15447739
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Citations for A 331440 dihydrochloride
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Currently there are no citations for A 331440 dihydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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