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Submit ReviewA 779
Description: Selective Mas receptor (Ang-(1-7) receptor) antagonist
Purity: ≥95% (HPLC)
Biological Activity for A 779
A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.
Technical Data for A 779
| M. Wt | 872.98 |
| Formula | C39H60N12O11 |
| Sequence |
DRVYIHA (Modifications: Ala-7 = D-Ala) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 159432-28-7 |
| PubChem ID | 10169886 |
| InChI Key | GZSZZUXDAPDPOR-NGIFJXEWSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 779
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for A 779
References for A 779
References are publications that support the biological activity of the product.
Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219 PMID: 25522140
Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433
Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293 PMID: 7850477
If you know of a relevant reference for A 779, please let us know.
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Keywords: A 779, A 779 supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Other, Angiotensin, Receptors, 5937, Tocris Bioscience
6 Citations for A 779
Citations are publications that use Tocris products. Selected citations for A 779 include:
Aviva J et al (2019) Subcutaneous Administration of Angiotensin-(1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma 36 3115-3131 PMID: 31037999
Felix et al (2022) The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes. Commun Biol 5 827 PMID: 35978143
Dominska et al (2018) Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci.Rep. 8 15772 PMID: 30361641
Tomasz et al (2020) The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes. Int J Mol Sci 21 PMID: 32872192
Hajime et al (2020) Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning. Sci Rep 10 2602 PMID: 32054947
Moreno-Santos et al (2021) Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav.Brain Res. 397 PMID: 33011187
Do you know of a great paper that uses A 779 from Tocris? Please let us know.
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