Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewA 85380 dihydrochloride
Discontinued Product
5017 has been discontinued.
Description: High affinity and selective α4β2 nAChR agonist
Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for A 85380 dihydrochloride
A 85380 dihydrochloride is a high affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.
Technical Data for A 85380 dihydrochloride
| M. Wt | 237.13 |
| Formula | C9H12N2O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 174740-86-4 |
| PubChem ID | 10399247 |
| InChI Key | GVEVDINKRFDXFP-JZGIKJSDSA-N |
| Smiles | [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 85380 dihydrochloride
References for A 85380 dihydrochloride
References are publications that support the biological activity of the product.
Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405
Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981
View Related Products by Target
View Related Products by Product Action
Keywords: A 85380 dihydrochloride, A 85380 dihydrochloride supplier, A85380, dihydrochloride, high, affinity, selective, nicotinic, receptors, cholinergic, acetylcholine, alpha4beta2, a4b2, α4β2, agonists, Nicotinic, (a4b2), Receptors, 5017, Tocris Bioscience
Citations for A 85380 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for A 85380 dihydrochloride.
Reviews for A 85380 dihydrochloride
There are currently no reviews for this product. Be the first to review A 85380 dihydrochloride and earn rewards!
Have you used A 85380 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.