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Submit Reviewα-Conotoxin EI
Discontinued Product
3124 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
Description: α1β1δγ selective nAChR antagonist
Biological Activity for α-Conotoxin EI
Selective antagonist of neuromuscular nicotinic receptors α1β1γδ. Displays selectivity for α/δ sites over α/γ sites in Torpedo.
Licensing Information
Sold under license from University of Utah
Technical Data for α-Conotoxin EI
| M. Wt | 2093.4 |
| Formula | C83H125N27O27S5 |
| Sequence |
RDXCCYHPTCNMSNPQIC (Modifications: X = Hyp, Cys-18 = C-terminal amide, Disulfide bridge between 4 - 10, 5 - 17) |
| Storage | Store at -20°C |
| CAS Number | 170663-33-9 |
| PubChem ID | 90488801 |
| InChI Key | ZUOKYBVKCMQKIN-MLWUHNSQSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O)[C@@H](C)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for α-Conotoxin EI
References for α-Conotoxin EI
References are publications that support the biological activity of the product.
Martinez et al (1995) α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry 34 14519 PMID: 7578057
Park et al (2001) Solution conformation of α-Conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor. J.Biol.Chem. 276 49028 PMID: 11641403
Lopez-Vera et al (2007) Novel α-conotoxins from Conus spurius and the α-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS Lett. 274 3972
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Keywords: alpha-Conotoxin EI, alpha-Conotoxin EI supplier, α1β1δγ, alpha1beta1deltagamma, a1b1dg, selective, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, EI, a-ConotoxinEI, conotoxins, venoms, (Other, Subtypes), 3124, Tocris Bioscience
Citations for α-Conotoxin EI
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Currently there are no citations for α-Conotoxin EI.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.