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Submit Reviewα-Conotoxin MII
Discontinued Product
1340 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
Description: Potent and selective α3β2 and β3 nAChR antagonist
Purity: ≥95% (HPLC)
Biological Activity for α-Conotoxin MII
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Licensing Information
Sold under license from the University of Utah.
Technical Data for α-Conotoxin MII
| M. Wt | 1710.99 |
| Formula | C67H103N23O22S4 |
| Sequence |
GCCSNPVCHLEHSNLC (Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 175735-93-0 |
| PubChem ID | 57340508 |
| InChI Key | DUQYFGMBLOPGBY-XCQLYXDWSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for α-Conotoxin MII
References for α-Conotoxin MII
References are publications that support the biological activity of the product.
Cartier et al (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 271 7522 PMID: 8631783
Harvey et al (1997) Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 51 336 PMID: 9203640
McIntosh et al (2000) Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 393 205 PMID: 10771014
David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 31 978 PMID: 20377613
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Keywords: alpha-Conotoxin MII, alpha-Conotoxin MII supplier, Potent, α3β2, alpha3beta2, a3b2, b3, β3, beta3, subunit, selective, nicotinic, antagonist, Acetylcholine, ACh, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, MII, a-ConotoxinMII, venoms, Nicotinic, (Other, Subtypes), 1340, Tocris Bioscience
1 Citation for α-Conotoxin MII
Citations are publications that use Tocris products. Selected citations for α-Conotoxin MII include:
Krais et al (2011) CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis 32 1388 PMID: 21586512
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.