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Submit Reviewα-Conotoxin PnIA
Discontinued Product
3123 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
Description: Selective α3β2 nAChR antagonist
Biological Activity for α-Conotoxin PnIA
α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).
Licensing Information
Sold under license from University of Utah
Technical Data for α-Conotoxin PnIA
| M. Wt | 1622.82 |
| Formula | C65H95N19O22S4 |
| Sequence |
GCCSLPPCAANNPDYC (Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16) |
| Storage | Desiccate at -20°C |
| CAS Number | 705300-84-1 |
| PubChem ID | 73755066 |
| InChI Key | VUVGEYBNLLGGBG-MVPSLEAZSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for α-Conotoxin PnIA
References for α-Conotoxin PnIA
References are publications that support the biological activity of the product.
Fainzilber et al (1994) New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523 PMID: 8068627
Luo et al (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542 PMID: 10545176
Everhart et al (2003) Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664 PMID: 12734390
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Keywords: alpha-Conotoxin PnIA, alpha-Conotoxin PnIA supplier, Selective, α3β2, alpha3beta2, a3b2, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, PnIA, conotoxins, venoms, (Other, Subtypes), 3123, Tocris Bioscience
Citations for α-Conotoxin PnIA
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Currently there are no citations for α-Conotoxin PnIA.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.