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Submit ReviewAA 29504
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene
Purity: ≥98% (HPLC)
Biological Activity for AA 29504
AA 29504 is a positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo.
Technical Data for AA 29504
| M. Wt | 327.42 |
| Formula | C19H25N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 945828-50-2 |
| PubChem ID | 23188887 |
| InChI Key | SCOOTUMXCXKEAD-UHFFFAOYSA-N |
| Smiles | NC1=C(NC(OCC)=O)C=CC(NCC2=C(C)C=C(C)C=C2C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AA 29504
References for AA 29504
References are publications that support the biological activity of the product.
Hoestgaard-Jensen et al (2010) Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors. Neuropharmacology 58 702 PMID: 20060846
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem. Pharmacol. PMID: 29454619
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Keywords: AA 29504, AA 29504 supplier, GABAA, positive, allosteric, modulators, pams, alpha4beta3delta, a4b3d, α4β3γ, anxiolytic, gamma-aminobutyric, acid, AA29504, Receptors, 3972, Tocris Bioscience
1 Citation for AA 29504
Citations are publications that use Tocris products. Selected citations for AA 29504 include:
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol. 150 305 PMID: 29454619
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.