Home / Pharmacology / Enzymes / Cytochrome P450 / Cytochrome P450 Inhibitors / Abiraterone acetate

Abiraterone acetate

Cat. No. 6520 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent CYP17A1 inhibitor
Chemical Name: (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Abiraterone acetate

Abiraterone acetate is a potent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

Compound Libraries for Abiraterone acetate

Abiraterone acetate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Abiraterone acetate

M. Wt 391.55
Formula C26H33NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 154229-18-2
PubChem ID 9821849
InChI Key UVIQSJCZCSLXRZ-UBUQANBQSA-N
Smiles [H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Abiraterone acetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.83 20
ethanol 39.16 100

Preparing Stock Solutions for Abiraterone acetate

The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Abiraterone acetate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Abiraterone acetate

References are publications that support the biological activity of the product.

Potter et al (1995) Novel steroidal inhibitors of human cytochrome P45017α (l7α-Hydroxylase-Cl7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 38 2463 PMID: 7608911

Barrie et al (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 50 267 PMID: 7918112

If you know of a relevant reference for Abiraterone acetate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Cytochrome P450 Inhibitors

Keywords: Abiraterone acetate, Abiraterone acetate supplier, Potent, cytochrome, P450, CYP17A1, inhibitors, inhibits, CYP450c17, 17,20-lyase, 17alpha-hydroxylase, androgen, synthesis, prostate, cancer, Cytochrome, 6520, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Abiraterone acetate

Citations are publications that use Tocris products.

Currently there are no citations for Abiraterone acetate. Do you know of a great paper that uses Abiraterone acetate from Tocris? Please let us know.

Reviews for Abiraterone acetate

There are currently no reviews for this product. Be the first to review Abiraterone acetate and earn rewards!

Have you used Abiraterone acetate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review