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Submit ReviewABP 688
Description: High affinity human mGlu5 antagonist
Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
Purity: ≥98% (HPLC)
Biological Activity for ABP 688
ABP 688 is a high affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).
Technical Data for ABP 688
| M. Wt | 240.3 |
| Formula | C15H16N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 924298-51-1 |
| PubChem ID | 11481862 |
| InChI Key | CNNZLFXCUQLKOB-BMRADRMJSA-N |
| Smiles | CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ABP 688
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.03 | 100 | |
| 1eq. HCl | 12.02 | 50 |
Preparing Stock Solutions for ABP 688
The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.16 mL | 20.81 mL | 41.61 mL |
| 5 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 10 mM | 0.42 mL | 2.08 mL | 4.16 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.83 mL |
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Product Datasheets for ABP 688
References for ABP 688
References are publications that support the biological activity of the product.
Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903 PMID: 17110115
If you know of a relevant reference for ABP 688, please let us know.
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Citations for ABP 688
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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