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Submit ReviewABT 594 hydrochloride
Description: Selective α4β2 nAChR agonist
Alternative Names: Tebanicline
Chemical Name: (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ABT 594 hydrochloride
ABT 594 hydrochloride is a selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.
Compound Libraries for ABT 594 hydrochloride
ABT 594 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ABT 594 hydrochloride
| M. Wt | 235.11 |
| Formula | C9H11ClN2O.HCL |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 203564-54-9 |
| PubChem ID | 72193963 |
| InChI Key | GYVARJONEFSAJB-OGFXRTJISA-N |
| Smiles | ClC1=NC=C(C=C1)OC[C@H]2CCN2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ABT 594 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.51 | 100 | |
| DMSO | 23.51 | 100 |
Preparing Stock Solutions for ABT 594 hydrochloride
The following data is based on the product molecular weight 235.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.25 mL | 21.27 mL | 42.53 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.51 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets for ABT 594 hydrochloride
References for ABT 594 hydrochloride
References are publications that support the biological activity of the product.
Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626
Lynch et al (2005) ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur.J.Pharmacol. 509 43 PMID: 15713428
Munro et al (2010) Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594. Neuropharmacology 59 208 PMID: 20562022
Mar et al (2017) MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl) 234 2837 PMID: 28744563
If you know of a relevant reference for ABT 594 hydrochloride, please let us know.
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Citations for ABT 594 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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