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Submit ReviewABT 724 trihydrochloride
Description: Potent and selective D4 partial agonist; proerectile
Chemical Name: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ABT 724 trihydrochloride
ABT 724 trihydrochloride is an ABT 724 is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine), which displays no agonist activity at D2 receptors (EC50 > 10 μM). ABT 724 is selective in rats in vivo and produces penile erection following i.c.v. administration, and increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. This compound displays minimal side effects.
External Portal information for ABT 724 trihydrochloride
The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of ABT 724 is reviewed on the chemical probes website.
Technical Data for ABT 724 trihydrochloride
| M. Wt | 402.75 |
| Formula | C17H19N5.3HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 587870-77-7 |
| PubChem ID | 16759165 |
| InChI Key | AZFUVPBLKQGSRI-UHFFFAOYSA-N |
| Smiles | Cl.Cl.Cl.C(N1CCN(CC1)C1=NC=CC=C1)C1=NC2=CC=CC=C2N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ABT 724 trihydrochloride
References for ABT 724 trihydrochloride
References are publications that support the biological activity of the product.
Stewart et al (2004) DA D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J.Med.Chem. 47 2348 PMID: 15084133
Cowart et al (2004) Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a DArgic agent with a novel mode of action for the potential treatment of erectile dysfunction. J.Med.Chem. 47 3853 PMID: 15239663
Brioni et al (2004) Activation of DA D4 receptors by ABT-724 induces penile erection in rats. Proc.Natl.Acad.Sci.USA 101 6758
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Literature in this Area
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