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Description: Cytochrome P450 inhibitor; inhibits 20-HETE synthesis
Chemical Name: 1H-Benzotriazol-1-amine
Purity: ≥98% (HPLC)
Biological Activity for ABT
ABT is a cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.
Technical Data for ABT
| M. Wt | 134.14 |
| Formula | C6H6N4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1614-12-6 |
| PubChem ID | 1367 |
| InChI Key | JCXKHYLLVKZPKE-UHFFFAOYSA-N |
| Smiles | NN2C1=CC=CC=C1N=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ABT
References for ABT
References are publications that support the biological activity of the product.
Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186 PMID: 4045721
Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67 PMID: 23658377
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Keywords: ABT, ABT supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Cytochrome, P450, 5038, Tocris Bioscience
1 Citation for ABT
Citations are publications that use Tocris products. Selected citations for ABT include:
Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65 PMID: 22418950
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