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Submit ReviewABX 464
Description: HIV RNA splicing modulator
Chemical Name: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Purity: ≥98% (HPLC)
Biological Activity for ABX 464
ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.
Technical Data for ABX 464
| M. Wt | 338.71 |
| Formula | C16H10ClF3N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1258453-75-6 |
| PubChem ID | 49846599 |
| InChI Key | OZOGDCZJYVSUBR-UHFFFAOYSA-N |
| Smiles | FC(F)(F)OC1=CC=C(C=C1)NC=2N=C3C(Cl)=CC=CC3=CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ABX 464
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.87 | 100 | |
| ethanol | 33.87 | 100 |
Preparing Stock Solutions for ABX 464
The following data is based on the product molecular weight 338.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.76 mL | 29.52 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.9 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for ABX 464
References for ABX 464
References are publications that support the biological activity of the product.
Campos et al (2015) Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology 12 30 PMID: 25889234
Vautrin et al (2018) Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing. Sci.Rep. 9 792 PMID: 30692590
If you know of a relevant reference for ABX 464, please let us know.
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Keywords: ABX 464, ABX 464 supplier, ABX464, HIV, RNA, splicing, regulators, modulators, CBC, cap, binding, complex, microRNA, miR-124, DNA,, and, Protein, Synthesis, 6460, Tocris Bioscience
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