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Submit ReviewAC 186
Description: Potent and selective ERβ agonist; neuroprotective
Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Purity: ≥99% (HPLC)
Biological Activity for AC 186
AC 186 is a potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
Compound Libraries for AC 186
AC 186 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AC 186
| M. Wt | 306.32 |
| Formula | C18H17F3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1421854-16-1 |
| PubChem ID | 71245042 |
| InChI Key | HSMUKSLNDJOZQG-UHFFFAOYSA-N |
| Smiles | FC1(F)CCC(C2=C(F)C=CC=C2)(C3=CC=C(O)C=C3)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 186
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.63 | 100 |
Preparing Stock Solutions for AC 186
The following data is based on the product molecular weight 306.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.26 mL | 16.32 mL | 32.65 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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Product Datasheets for AC 186
References for AC 186
References are publications that support the biological activity of the product.
George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537 PMID: 24020966
McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249 PMID: 23898966
If you know of a relevant reference for AC 186, please let us know.
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1 Citation for AC 186
Citations are publications that use Tocris products. Selected citations for AC 186 include:
Hanna S et al (2022) Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer. Front Oncol 12 857590 PMID: 35574319
Do you know of a great paper that uses AC 186 from Tocris? Please let us know.
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