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Submit ReviewAc-RYYRIK-NH2
Description: High affinity NOP ligand
Biological Activity for Ac-RYYRIK-NH2
Ac-RYYRIK-NH2 is a high affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.
Technical Data for Ac-RYYRIK-NH2
| M. Wt | 939.12 |
| Formula | C44H70N14O9 |
| Sequence |
RYYRIK (Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 200959-48-4 |
| PubChem ID | 9963005 |
| InChI Key | WBBBVZGQADABSU-RERZDIOCSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ac-RYYRIK-NH2
Certificate of Analysis is currently unavailable on-line.
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References for Ac-RYYRIK-NH2
References are publications that support the biological activity of the product.
Berger et al (1999) Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 126 555 PMID: 10188961
Berger et al (1999) Acetyl-RYYRIK-NH2, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 80 122 PMID: 10998548
Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393
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Keywords: Ac-RYYRIK-NH2, Ac-RYYRIK-NH2 supplier, High, affinity, NOP, ligands, Nociceptin, Receptors, ORL1, OP4, Opioid, 1239, Tocris Bioscience
Citations for Ac-RYYRIK-NH2
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