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Submit ReviewAc-RYYRWK-NH2
Description: Potent, selective NOP partial agonist peptide
Biological Activity for Ac-RYYRWK-NH2
Ac-RYYRWK-NH2 is a potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.
Technical Data for Ac-RYYRWK-NH2
| M. Wt | 1012.17 |
| Formula | C49H69N15O9 |
| Sequence |
RYYRWK (Modifications: Arg-1 = C-terminal Ac, Lys-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 200959-47-3 |
| PubChem ID | 9811889 |
| InChI Key | YROQVQIJRORFAZ-SKGSPYGFSA-N |
| Smiles | CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ac-RYYRWK-NH2
References for Ac-RYYRWK-NH2
References are publications that support the biological activity of the product.
Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393
Ho et al (2000) Characterization of the ORL1 receptor on adrenergic nerve in the rat anococcygeus. Br.J.Pharmacol. 131 349 PMID: 10991930
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Keywords: Ac-RYYRWK-NH2, Ac-RYYRWK-NH2 supplier, Potent, selective, NOP, partial, agonists, peptide, Nociceptin, Receptors, ORL1, OP4, Opioid, 1387, Tocris Bioscience
Citations for Ac-RYYRWK-NH2
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Currently there are no citations for Ac-RYYRWK-NH2.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.