Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAcarbose
Description: Glucosidase α inhibitor (intestinal)
Alternative Names: Bay-g 5421
Chemical Name: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose
Biological Activity for Acarbose
Acarbose is an inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.
Compound Libraries for Acarbose
Acarbose is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Acarbose
| M. Wt | 645.25 |
| Formula | C25H43NO18 |
| Storage | Desiccate at RT |
| CAS Number | 56180-94-0 |
| PubChem ID | 444254 |
| InChI Key | XUFXOAAUWZOOIT-SXARVLRPSA-N |
| Smiles | C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Acarbose
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 64.52 | 100 | |
| DMSO | 64.52 | 100 |
Preparing Stock Solutions for Acarbose
The following data is based on the product molecular weight 645.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.55 mL | 7.75 mL | 15.5 mL |
| 5 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.55 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Acarbose
References for Acarbose
References are publications that support the biological activity of the product.
Krause et al (1982) Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor aca. (BAY g 5421). Digestion 23 232 PMID: 6754513
Balfour and McTavish (1993) Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 46 1025 PMID: 7510610
Oki et al (2000) Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 23 1084 PMID: 10993209
If you know of a relevant reference for Acarbose, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Acarbose, Acarbose supplier, Glucosidase, alpha, inhibitors, inhibits, intestinal, Glycosylases, Carbohydrate, Metabolism, Bay-g5421, Bay-g, 5421, 2673, Tocris Bioscience
Citations for Acarbose
Citations are publications that use Tocris products.
Currently there are no citations for Acarbose. Do you know of a great paper that uses Acarbose from Tocris? Please let us know.
Reviews for Acarbose
There are currently no reviews for this product. Be the first to review Acarbose and earn rewards!
Have you used Acarbose?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image