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Submit ReviewACDPP hydrochloride
Discontinued Product
2254 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Selective mGlu5 antagonist
Chemical Name: 3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ACDPP hydrochloride
Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.
Technical Data for ACDPP hydrochloride
| M. Wt | 329.19 |
| Formula | C12H13ClN6O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| PubChem ID | 16759168 |
| InChI Key | CXIHLPLRTFPHKX-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)C1=C(Cl)N=C(C(=O)NC2=CN=CC=C2)C(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ACDPP hydrochloride
References for ACDPP hydrochloride
References are publications that support the biological activity of the product.
Bonnefous et al (2005) Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 15 1197 PMID: 15686941
Wang et al (2008) Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 28 4385 PMID: 18434517
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Keywords: ACDPP hydrochloride, ACDPP hydrochloride supplier, Selective, mGlu5, mGluR5, receptor, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic, 37804-11-8, 1224196-38-6, (Metabotropic), 2254, Tocris Bioscience
Citations for ACDPP hydrochloride
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Currently there are no citations for ACDPP hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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