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Discontinued Product
1112 has been discontinued.
View all Non-selective Metabotropic Glutamate products.
Description: Competitive mGlu receptor antagonist
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity for ACPT-II
ACPT-II is a competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Licensing Information
Sold with the permission of the CNRS
Technical Data for ACPT-II
| M. Wt | 217.18 |
| Formula | C8H11NO6 |
| Storage | Desiccate at -20°C |
| CAS Number | 195209-04-2 |
| PubChem ID | 6604820 |
| InChI Key | FERIKTBTNCSGJS-OBLUMXEWSA-N |
| Smiles | N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ACPT-II
References for ACPT-II
References are publications that support the biological activity of the product.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600
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Keywords: ACPT-II, ACPT-II supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, 1112, Tocris Bioscience
2 Citations for ACPT-II
Citations are publications that use Tocris products. Selected citations for ACPT-II include:
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593 PMID: 11016958
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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