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Submit ReviewACT 335827
Description: Potent and selective OX1 antagonist
Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
Purity: ≥98% (HPLC)
Biological Activity for ACT 335827
ACT 335827 is a potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.
Technical Data for ACT 335827
| M. Wt | 518.64 |
| Formula | C31H38N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1354039-86-3 |
| PubChem ID | 54765113 |
| InChI Key | HXHOBPVRRPCTLG-SETSBSEESA-N |
| Smiles | O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ACT 335827
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.86 | 100 | |
| ethanol | 51.86 | 100 |
Preparing Stock Solutions for ACT 335827
The following data is based on the product molecular weight 518.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.64 mL | 19.28 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Product Datasheets for ACT 335827
References for ACT 335827
References are publications that support the biological activity of the product.
Steiner et al (2013) Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 8 898 PMID: 23589487
If you know of a relevant reference for ACT 335827, please let us know.
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Keywords: ACT 335827, ACT 335827 supplier, ACT335827, potent, selective, OX1, antagonists, orexin-1, orexin1, orally, available, brain, penetrant, receptors, Receptor, 4983, Tocris Bioscience
Citations for ACT 335827
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