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Submit ReviewAdaptaquin
Description: HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity: ≥97% (HPLC)
Biological Activity for Adaptaquin
Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.
Technical Data for Adaptaquin
| M. Wt | 377.82 |
| Formula | C21H16ClN3O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 385786-48-1 |
| PubChem ID | 3740671 |
| InChI Key | KKYHNYRUBSYTCZ-UHFFFAOYSA-N |
| Smiles | OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Adaptaquin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.78 | 100 |
Preparing Stock Solutions for Adaptaquin
The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.23 mL | 26.47 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.29 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets for Adaptaquin
References for Adaptaquin
References are publications that support the biological activity of the product.
Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29 PMID: 26936506
Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214 PMID: 27148687
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Keywords: Adaptaquin, Adaptaquin supplier, HIF-PHD, inhibitors, hypoxia, inducible, factor, prolyl, hydroxylases, inhibits, antioxidant, neuroprotective, brain, penetrant., Hypoxia, Inducible, Factors, Hydroxylases, 5953, Tocris Bioscience
1 Citation for Adaptaquin
Citations are publications that use Tocris products. Selected citations for Adaptaquin include:
Saravanan S et al (2021) HIF1α stabilization in hypoxia is not oxidant-initiated. Elife 10 PMID: 34596045
Do you know of a great paper that uses Adaptaquin from Tocris? Please let us know.
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