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Submit ReviewAdenosine
Description: Endogenous adenosine receptor agonist
Chemical Name: 9-β-D-Ribofuranosyl-9H-purin-6-amine
Purity: ≥99% (HPLC)
Biological Activity for Adenosine
Adenosine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes.
Compound Libraries for Adenosine
Adenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Adenosine
| M. Wt | 267.24 |
| Formula | C10H13N5O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 58-61-7 |
| PubChem ID | 60961 |
| InChI Key | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Adenosine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.67 | 10 | |
| DMSO | 20.04 | 75 |
Preparing Stock Solutions for Adenosine
The following data is based on the product molecular weight 267.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.99 mL | 24.95 mL | 49.89 mL |
| 3.75 mM | 1 mL | 4.99 mL | 9.98 mL |
| 7.5 mM | 0.5 mL | 2.49 mL | 4.99 mL |
| 37.5 mM | 0.1 mL | 0.5 mL | 1 mL |
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Product Datasheets for Adenosine
References for Adenosine
References are publications that support the biological activity of the product.
Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376
If you know of a relevant reference for Adenosine, please let us know.
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Keywords: Adenosine, Adenosine supplier, Endogenous, adenosines, receptor, agonists, Non-Selective, Receptors, Non-selective, Adenosine, 3624, Tocris Bioscience
6 Citations for Adenosine
Citations are publications that use Tocris products. Selected citations for Adenosine include:
Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated J Neurosci 339 886 PMID: 21896918
Giovanni et al (2021) Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK. Neuron 109 2256-2274.e9 PMID: 34139149
Bruce R et al (2022) Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses. Cell Rep 39 110727 PMID: 35443187
Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. PLoS One 32 14489 PMID: 23077035
Do you know of a great paper that uses Adenosine from Tocris? Please let us know.
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