Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewADU-S100 disodium salt
Description: STING agonist
Chemical Name: [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium
Purity: ≥95% (HPLC)
Biological Activity for ADU-S100 disodium salt
ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.
Technical Data for ADU-S100 disodium salt
| M. Wt | 734.5 |
| Formula | C20H22N10Na2O10P2S2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1638750-95-4 |
| PubChem ID | 135390762 |
| InChI Key | GDWOOOCBNOMMTL-ITQXCAEYSA-L |
| Smiles | O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)O[C@]1([H])CO[P@@]([S-])(O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@@]([S-])(O2)=O)=O.[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ADU-S100 disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.67 | 5 |
Preparing Stock Solutions for ADU-S100 disodium salt
The following data is based on the product molecular weight 734.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 27.23 mL | 136.15 mL | 272.29 mL |
| 0.25 mM | 5.45 mL | 27.23 mL | 54.46 mL |
| 0.5 mM | 2.72 mL | 13.61 mL | 27.23 mL |
| 2.5 mM | 0.54 mL | 2.72 mL | 5.45 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ADU-S100 disodium salt
References for ADU-S100 disodium salt
References are publications that support the biological activity of the product.
Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818
Zaidi et al (2021) Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 12 292 PMID: 33659041
If you know of a relevant reference for ADU-S100 disodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ADU-S100 disodium salt, ADU-S100 disodium salt supplier, STING, agonist, agonism, apoptosis, signaling, cancer, in, vivo, T-cells, immunity, antitumor, CD8+, STING-Dependent, Signaling, 7706, Tocris Bioscience
Citations for ADU-S100 disodium salt
Citations are publications that use Tocris products.
Currently there are no citations for ADU-S100 disodium salt. Do you know of a great paper that uses ADU-S100 disodium salt from Tocris? Please let us know.
Reviews for ADU-S100 disodium salt
There are currently no reviews for this product. Be the first to review ADU-S100 disodium salt and earn rewards!
Have you used ADU-S100 disodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image