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Submit ReviewADX 10059 hydrochloride
Description: Negative allosteric modulator of mGlu5 receptors
Alternative Names: Raseglurant
Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ADX 10059 hydrochloride
ADX 10059 hydrochloride is reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
Compound Libraries for ADX 10059 hydrochloride
ADX 10059 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ADX 10059 hydrochloride
| M. Wt | 276.74 |
| Formula | C15H13FN2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 757949-98-7 |
| PubChem ID | 18454771 |
| InChI Key | BDXXMGYKLQZXOU-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=NC(C#CC2=CC=CC(F)=C2)=C1N.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ADX 10059 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.92 | 25 | |
| DMSO | 27.67 | 100 |
Preparing Stock Solutions for ADX 10059 hydrochloride
The following data is based on the product molecular weight 276.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.07 mL | 36.14 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.23 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets for ADX 10059 hydrochloride
References for ADX 10059 hydrochloride
References are publications that support the biological activity of the product.
Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891 PMID: 21757343
Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192 PMID: 19460767
Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555 PMID: 20218930
If you know of a relevant reference for ADX 10059 hydrochloride, please let us know.
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Citations for ADX 10059 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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