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Description: Potent M2/M4 antagonist
Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for AF-DX 384
AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).
Technical Data for AF-DX 384
| M. Wt | 478.64 |
| Formula | C27H38N6O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 118290-26-9 |
| PubChem ID | 119357 |
| InChI Key | MZDYABXXPZNUCT-UHFFFAOYSA-N |
| Smiles | CCCN(CCC)CC1CCCCN1CCNC(=O)N1C2=C(C=CC=C2)C(=O)NC2=C1N=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AF-DX 384
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.93 | 50 | |
| ethanol | 4.79 | 10 |
Preparing Stock Solutions for AF-DX 384
The following data is based on the product molecular weight 478.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.18 mL | 20.89 mL | 41.79 mL |
| 2.5 mM | 0.84 mL | 4.18 mL | 8.36 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets for AF-DX 384
References for AF-DX 384
References are publications that support the biological activity of the product.
Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562 PMID: 7616446
Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283 PMID: 19111597
Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601 PMID: 1941609
If you know of a relevant reference for AF-DX 384, please let us know.
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Keywords: AF-DX 384, AF-DX 384 supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384, M2, 1345, Tocris Bioscience
Citations for AF-DX 384
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