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Submit ReviewAH 11110 hydrochloride
Discontinued Product
0998 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: Subtype-selective α1B ligand
Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for AH 11110 hydrochloride
AH 11110 hydrochloride is a subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.
Technical Data for AH 11110 hydrochloride
| M. Wt | 374.91 |
| Formula | C21H26N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 179388-65-9 |
| PubChem ID | 9907616 |
| InChI Key | WWHGFIXWBLHHQB-UHFFFAOYSA-N |
| Smiles | Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AH 11110 hydrochloride
References for AH 11110 hydrochloride
References are publications that support the biological activity of the product.
Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009
Saussy et al (1996) Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344
King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526
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Citations for AH 11110 hydrochloride
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.