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Description: Potent inhibitor of androgen receptor (AR)
Chemical Name: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
Purity: ≥98% (HPLC)
Biological Activity for Ailanthone
Ailanthone is a potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.
Technical Data for Ailanthone
| M. Wt | 376.4 |
| Formula | C20H24O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 981-15-7 |
| PubChem ID | 72965 |
| InChI Key | WBBVXGHSWZIJST-RLQYZCPESA-N |
| Smiles | C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ailanthone
References for Ailanthone
References are publications that support the biological activity of the product.
He et al (2015) Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat.Commun. 7 13122 PMID: 27959342
Zhuo et al (2015) Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Sci.Rep. 5 16185 PMID: 26525771
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Keywords: Ailanthone, Ailanthone supplier, Inhibitors, Inhibits, AR, Androgen, Receptor, p23, HSP90, Ubiquitin, Protease, System, UPS, apoptosis, prostate, cancer, Huh7, CRPC, castration-resistant, 6161, Tocris Bioscience
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