Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAKOS 022
Description: Voltage-dependent anion channel (VDAC) inhibitor
Chemical Name: 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)
Biological Activity for AKOS 022
AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.
Compound Libraries for AKOS 022
AKOS 022 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AKOS 022
| M. Wt | 467.87 |
| Formula | C22H21ClF3N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 878983-38-1 |
| PubChem ID | 5304523 |
| InChI Key | ZZVCWIMICOFQNJ-UHFFFAOYSA-N |
| Smiles | FC(F)(OC1=CC=C(C=C1)NC2CCN(C3CC(N(C4=CC=C(C=C4)Cl)C3=O)=O)CC2)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AKOS 022
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.79 | 100 |
Preparing Stock Solutions for AKOS 022
The following data is based on the product molecular weight 467.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.69 mL | 21.37 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for AKOS 022
References for AKOS 022
References are publications that support the biological activity of the product.
Ben-Hail et al (2016) Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction. J.Biol.Chem. 291 24986 PMID: 27738100
Zhang et al (2019) Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells. Cell Metab. 29 64 PMID: 30293774
If you know of a relevant reference for AKOS 022, please let us know.
View Related Products by Target
Keywords: AKOS 022, AKOS 022 supplier, AKOS022, AKOS022075291, AKOS, 022075291, voltage-dependent, anion, channel, VDAC, inhibitors, inhibits, anti-apoptotic, Other, Channel, Modulators, 7135, Tocris Bioscience
Citations for AKOS 022
Citations are publications that use Tocris products.
Currently there are no citations for AKOS 022. Do you know of a great paper that uses AKOS 022 from Tocris? Please let us know.
Reviews for AKOS 022
There are currently no reviews for this product. Be the first to review AKOS 022 and earn rewards!
Have you used AKOS 022?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image