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Submit ReviewAllopregnanolone
Description: Positive allosteric modulator of GABAA receptors
Alternative Names: 3a,5a-THPROG
Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Biological Activity for Allopregnanolone
Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
Technical Data for Allopregnanolone
| M. Wt | 318.49 |
| Formula | C21H34O2 |
| Storage | Store at RT |
| CAS Number | 516-54-1 |
| PubChem ID | 92786 |
| InChI Key | AURFZBICLPNKBZ-SYBPFIFISA-N |
| Smiles | C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Allopregnanolone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
Preparing Stock Solutions for Allopregnanolone
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Allopregnanolone
References for Allopregnanolone
References are publications that support the biological activity of the product.
Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838
Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466
Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602
If you know of a relevant reference for Allopregnanolone, please let us know.
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Keywords: Allopregnanolone, Allopregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, PAM, 3a,5a-THPROG, Receptors, 3653, Tocris Bioscience
4 Citations for Allopregnanolone
Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:
Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337 301 PMID: 21262851
Michael et al (2021) Placental endocrine function shapes cerebellar development and social behavior. Nat Neurosci 24 1392-1401 PMID: 34400844
Scott M et al (2020) Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology 45 1263 PMID: 32045935
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647
Do you know of a great paper that uses Allopregnanolone from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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