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Submit ReviewAM 1172
Description: Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist
Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide
Purity: ≥98% (HPLC)
Biological Activity for AM 1172
AM 1172 is a metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively). FABP inhibitor.
Technical Data for AM 1172
| M. Wt | 409.6 |
| Formula | C27H39NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 251908-92-6 |
| PubChem ID | 10364179 |
| InChI Key | XCWBOAHOJHPWLA-DOFZRALJSA-N |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCNC(C1=CC=C(O)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AM 1172
References for AM 1172
References are publications that support the biological activity of the product.
Kaczocha et al (2006) Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 281 9066 PMID: 16461355
Hillard et al (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 33 18 PMID: 17901541
Fegley et al (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA 101 8756
Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143
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Keywords: AM 1172, AM 1172 supplier, Anandamide, uptake, inhibitors, inhibits, AMT, FAAH, inhibitor, CB, receptors, partial, agonists, cannabinoid, fatty, acid, amide, hydrolase, neurotransmitter, transporters, AM1172, cb2r, cb1r, FABP, FABPs, binding, protein, Cannabinoid, Transporters, Non-selective, Cannabinoids, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Binding, Proteins, 3381, Tocris Bioscience
Citations for AM 1172
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Currently there are no citations for AM 1172.
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